Che Chen Selected Research

Leukemia

1/2020	Emodin and AZT synergistically inhibit the proliferation and induce the apoptosis of leukemia K562 cells through the EGR1 and the Wnt/β‑catenin pathway.
10/2018	[Effects of Tcd A on Rho GTPases and the Cytoskeleton of Leukemia Cell Line K562].
10/2015	[Effect of Emodin Combined with AZT on the Proliferation and the Expression of BCL-2, NF-κB, TGF-β in the Leukemia Stem Cells-KG-1a cells].
4/2015	[Effects of the Combination of Emodin and 3'-Azido-3'-Deoxythymidine on Proliferation and Apoptosis in leukemia KG-1a cells Transfected with Egr-1 siRNA].
4/2012	[Effects of AZT on leukemia cell line KG-1a proliferation and telomerase activity].
6/2011	[Apoptosis-inducing effect of clostridium difficile toxin A on K562 cells and its mechanism].
2/2005	[An experimental study on proliferative effects and apoptotic effects of podophyllic acid in K562 cells].

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Che Chen Research Topics

Disease

14	Neoplasms (Cancer) 12/2023 - 02/2003
8	Stomach Neoplasms (Stomach Cancer) 12/2023 - 08/2007
7	Leukemia 01/2020 - 02/2005
6	Carcinoma (Carcinomatosis) 09/2017 - 02/2003
5	Colorectal Neoplasms (Colorectal Cancer) 01/2017 - 09/2004
5	Rectal Neoplasms (Rectal Cancer) 11/2014 - 01/2005
4	Carcinogenesis 01/2015 - 06/2005
2	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 01/2020 - 12/2013
2	Hepatocellular Carcinoma (Hepatoma) 01/2018 - 06/2011
2	Stroke (Strokes) 05/2016 - 02/2015
2	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 10/2015 - 04/2012
1	Inflammation (Inflammations) 01/2023
1	Gastritis 04/2021
1	Neoplasm Metastasis (Metastasis) 01/2017
1	Weight Gain 10/2016
1	Gestational Diabetes (Gestational Diabetes Mellitus) 10/2016
1	Hemorrhage 05/2016
1	Edema (Dropsy) 05/2016
1	Hematoma 05/2016
1	Breast Neoplasms (Breast Cancer) 12/2015
1	Lymphatic Metastasis 01/2015
1	Colonic Neoplasms (Colon Cancer) 01/2015
1	Hematologic Neoplasms (Hematological Malignancy) 01/2015
1	Residual Neoplasm 11/2014
1	Double Outlet Right Ventricle 06/2013
1	Ventricular Heart Septal Defects (Ventricular Septal Defect) 06/2013
1	Acute Erythroblastic Leukemia (Erythroleukemia) 05/2012
1	Adenocarcinoma 12/2007
1	Polyps 12/2007
1	Adenoma (Adenomas) 12/2007

Drug/Important Bio-Agent (IBA)

7	Messenger RNA (mRNA)IBA 01/2016 - 09/2004
6	Zidovudine (Retrovir)FDA LinkGeneric 01/2018 - 08/2007
5	Proteins (Proteins, Gene)FDA Link 01/2015 - 01/2005
5	Somatotropin Receptors (Growth Hormone Receptor)IBA 07/2014 - 09/2004
4	Emodin (Archin)IBA 01/2020 - 12/2013
3	Indicators and Reagents (Reagents)IBA 01/2016 - 05/2006
3	Growth Hormone (Somatotropin)IBA 07/2014 - 09/2004
3	Telomerase (Telomerase Reverse Transcriptase)IBA 04/2012 - 08/2007
2	Arsenic Trioxide (Trisenox)FDA Link 01/2018 - 06/2011
2	Small Interfering RNA (siRNA)IBA 04/2015 - 01/2015
1	Interleukin-1 Receptor Accessory ProteinIBA 01/2023
1	Ribosomal DNA (rDNA)IBA 04/2021
1	rho GTP-Binding Proteins (rho GTP-Binding Protein)IBA 10/2018
1	Early Growth Response Protein 1IBA 01/2018
1	Antisense RNA (Anti-Sense RNA)IBA 09/2017
1	Paclitaxel (Taxol)FDA LinkGeneric 01/2017
1	TOR Serine-Threonine KinasesIBA 01/2017
1	Ribosomal Protein S6 Kinases (S6 Kinase)IBA 01/2017
1	Blood Glucose (Blood Sugar)IBA 10/2016
1	Glucose (Dextrose)FDA LinkGeneric 10/2016
1	LigandsIBA 01/2016
1	Notch ReceptorsIBA 01/2016
1	formononetinIBA 12/2015
1	Sunitinib (Sutent)FDA Link 12/2015
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 12/2015
1	Fetal Proteins (Fetoprotein)IBA 12/2015
1	Fluorouracil (Carac)FDA LinkGeneric 10/2015
1	heparanaseIBA 01/2015
1	Indomethacin (Indometacin)FDA LinkGeneric 01/2015
1	Chalcone (Benzalacetophenone)IBA 01/2015
1	Tretinoin (Retinoic Acid)FDA LinkGeneric 01/2015
1	Dinoprostone (PGE2)FDA Link 01/2015
1	Prostaglandin E Receptors (Prostaglandin E Receptor)IBA 01/2015
1	Cyclooxygenase 2 (Cyclooxygenase-2)IBA 01/2015
1	Cyclooxygenase 2 Inhibitors (COX-2 Inhibitors)IBA 01/2015
1	Insulin-Like PeptidesIBA 11/2014
1	Biomarkers (Surrogate Marker)IBA 11/2014
1	Human Growth Hormone (Saizen)FDA LinkGeneric 07/2014
1	3' Untranslated Regions (3' UTR)IBA 02/2014
1	Transforming Growth Factor alpha (TGF-alpha)IBA 02/2014
1	3- ((4- (6- bromo- 2- (4- (4- methylpiperazin- 1- yl)phenyl)- 3H- imidazo(4,5- b)pyridin- 7- yl)piperazin- 1- yl)methyl)- 5- methylisoxazoleIBA 01/2014
1	Member 1 Subfamily B ATP Binding Cassette TransporterIBA 12/2013
1	Antineoplastic Agents (Antineoplastics)IBA 12/2013
1	Staphylococcal Protein A (Protein A)IBA 12/2013
1	Doxorubicin (Adriamycin)FDA LinkGeneric 12/2013
1	FlavonoidsIBA 05/2012
1	Proto-Oncogene Proteins p21(ras)IBA 05/2012
1	Proliferating Cell Nuclear Antigen (PCNA)IBA 05/2012
1	Clostridium difficile tcdA proteinIBA 06/2011
1	Caspase 3 (Caspase-3)IBA 06/2011
1	CadmiumIBA 06/2008
1	AntibodiesIBA 12/2007
1	RNA (Ribonucleic Acid)IBA 08/2007
1	Codon (Codons)IBA 06/2005
1	podophyllic acidIBA 02/2005
1	LuminolIBA 02/2003
1	Mitomycin (Mitomycin-C)FDA LinkGeneric 02/2003

Therapy/Procedure

6	Drug Therapy (Chemotherapy) 12/2023 - 02/2003
5	Radiotherapy 11/2014 - 01/2005
3	Neoadjuvant Therapy 12/2023 - 11/2014
2	Therapeutics 05/2016 - 12/2015
2	Activities of Daily Living (ADL) 05/2016 - 02/2015
2	Intra-Arterial Infusions 12/2015 - 11/2014
1	Nutrition Therapy (Medical Nutrition Therapy) 10/2016
1	Chemoradiotherapy 01/2014
1	Arterial Switch Operation 06/2013
1	Adjuvant Radiotherapy 06/2005